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What do you know about CVD protective factors besides HDL? Have you heard of “Endothelial Resilience”?

Arterioscler Thromb Vasc Biol 2020 Oct 22

Exploring the Role of Endothelial Cell Resilience in Cardiovascular Health and Disease
Yunling Gao 1, Zorina S Galis 1

Affiliation

• 1
• From the Division of Cardiovascular Sciences, Vascular Biology and Hypertension Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
• PMID: 33086867 DOI: 10.1161/ATVBAHA.120.314346

Abstract
Traditionally, much research effort has been invested into focusing on disease, understanding pathogenic mechanisms, identifying risk factors, and developing effective treatments. A few recent studies unraveling the basis for absence of disease, including cardiovascular disease, despite existing risk factors, a phenomenon commonly known as resilience, are adding new knowledge and suggesting novel therapeutic approaches. Given the central role of endothelial function in cardiovascular health, we herein provide a number of considerations that warrant future research and considering a paradigm shift toward identifying the molecular underpinnings of endothelial resilience.
Keywords: COVID-19; cardiovascular disease; endothelial cells; nitric oxide; vascular endothelium.

Correspondence to: Yunling Gao, PhD, Division of Cardiovascular Sciences, Vascular Biology and Hypertension Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 6705 Rockledge Dr, Bethesda, MD 20817. Email gaoy2@nhlbi.nih.gov

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