Stop These Two Cardiovascular Criminals! Insulin Resistance and Endothelial Dysfunction

Mediators Inflamm. 2016 /3634948

Insulin Resistance and Endothelial Dysfunction Constitute a Common Therapeutic Target in Cardiometabolic Disorders.

Janus A, Szahidewicz-Krupska E, Mazur G, Doroszko A.


Insulin resistance and other risk factors for atherosclerosis, such as hypertension and hypercholesterolemia, promote endothelial dysfunction and lead to development of metabolic syndrome which constitutes an introduction to cardiovascular disease. The insulin resistance and endothelial dysfunction cross talk between each other by numerous metabolic pathways. Hence, targeting one of these pathologies with pleiotropic treatment exerts beneficial effect on another one. Combined and expletive treatment of hypertension, lipid disorders, and insulin resistance with nonpharmacological interventions and conventional pharmacotherapy may inhibit the transformation of metabolic disturbances to fully developed cardiovascular disease. This paper summarises the common therapeutic targets for insulin resistance, endothelial dysfunction, and vascular inflammatory reaction at molecular level and analyses the potential pleiotropic effects of drugs used currently in management of cardiovascular disease, metabolic syndrome, and diabetes.

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See a related pioneering article published 10yrs ago

Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):423-36.

Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases.

Cersosimo E, DeFronzo RA.

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