Oxilized Lipoprotein(a) and Endothelial Dysfunction in Patients with Type 2 Diabetes

Int J Mol Sci. 2019 Oct 3;20(19).
The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus.
Kotani K1,2, Yamada S3, Takahashi H4, Iwazu Y5, Yamada T6.
Author information
1 Division of Community and Family Medicine, Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan. kazukotani@jichi.ac.jp.
2 Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan. kazukotani@jichi.ac.jp.
3 Central Laboratory, Shino-Test, Sagamihara-City, Kanagawa 252-0331, Japan. shingo.yamada@shino-test.co.jp.
4 Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga-City, Saga 849-8501, Japan. takahas2@cc.saga-u.ac.jp.
5 Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan. iwazu@jichi.ac.jp.
6 Department of Clinical Laboratory Medicine, Jichi Medical University, Shimotsuke-City, Tochigi 329-0498, Japan. yamadanji@jichi.ac.jp.
Abstract
The ratio of oxidized lipoprotein(a) to native lipoprotein(a) (oxLp(a)/Lp(a)) may be a reasonable index for assessing endothelial dysfunction in type 2 diabetes mellitus (T2DM). The present study investigated whether the oxLp(a)/Lp(a) level is correlated with the endothelial function using the Endo-PATTM, a newly developed device, in patients with T2DM. A total of 63 patients with T2DM (mean age: 59 years old) were enrolled in the study. The patients’ serum Lp(a) and oxLp(a) levels were measured using an enzyme-linked immunosorbent assay. The reactive hyperemia index (RHI) level was measured using an Endo-PATTM 2000. A correlation analysis between the measured variables was conducted. Among the patients, the mean hemoglobin A1c was 7.8%. The median level of oxLp(a)/Lp(a) was 0.28 (interquartile range: 0.07-0.54), and the mean RHI was 1.8 (standard deviation: 0.4). In a multiple linear regression analysis, the oxLp(a)/Lp(a) level was an independent, significant, and inverse variable for the RHI level (β = -0.26, p < 0.05), along with male gender. A high oxLp(a)/Lp(a) level may reflect endothelial dysfunction, as assessed by the Endo-PATTM, in patients with T2DM. Further studies are warranted to confirm the observed findings.
KEYWORDS:
Endo-PAT; Lp(a); atherosclerosis; endothelium; oxidative stress; reactive hyperemia
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