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New Study Shows How to Prevent Sitting-Induced Leg Endothelial Dysfunction

Clin Sci (Lond). 2017 Apr 6. pii: CS20170031. doi: 10.1042/CS20170031. [Epub ahead of print]

Prior exercise and standing as strategies to circumvent sitting-induced leg endothelial dysfunction.

Morishima T1, Restaino RM2, Walsh LK3, Kanaley JA1, Padilla J4.

Author information

University of Missouri, Columbia, Missouri, 65211, United States.
Medical Pharmacology and Physiology, Univeristy of Missouri, Columbia, Missouri, 65211, United States.
Nutrition and Exercise Physiology, University of Missouri, 204 Gwynn Hall, Columbia, Missouri, 65211, United States.
Biomedical Sciences, University of Missouri, 1600 E. Rollins, E102 Vet Med Bldg, Columbia, Missouri, 65211, United States


We have previously shown that local heating or leg fidgeting can prevent prolonged sitting-induced leg endothelial dysfunction. However, whether physical activity prevents subsequent sitting-induced leg endothelial dysfunction remains unknown. Herein, we tested the hypothesis that sitting-induced leg endothelial dysfunction would be prevented by prior exercise. We also examined if, in the absence of exercise, standing is an effective alternative strategy to sitting for conserving leg endothelial function. Fifteen young healthy subjects completed three randomized experimental trials: 1) sitting without prior exercise; 2) sitting with prior exercise; and 3) standing without prior exercise. Following baseline popliteal artery flow-mediated dilation (FMD) measurements, subjects maintained a supine position for 45 min in the sitting and standing trials, without prior exercise, or performed 45 min of leg cycling before sitting (i.e., sitting with prior exercise trial). Thereafter, subjects were positioned into a seated or standing position, according to the trial, for 3 hours. Popliteal artery FMD measures were then repeated. Three hours of sitting without prior exercise caused a significant impairment in popliteal artery FMD (baseline: 3.8±0.5%, post-sitting: 1.5±0.5%, p 0.05), which was prevented when sitting was preceded by a bout of cycling exercise (baseline: 3.8±0.5%, post-sitting: 3.6±0.7%, p 0.05). Three hours of standing did not significantly alter popliteal artery FMD (baseline: 4.1±0.4%, post-standing: 4.3±0.4%, p 0.05).

In conclusion, prolonged sitting-induced leg endothelial dysfunction can be prevented by prior aerobic exercise. In addition, in the absence of exercise, standing represents an effective substitute to sitting for preserving leg conduit artery endothelial function.

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