New Discovery Links Endothelial Dysfunction to Brain Dysfunction

Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness
Anesthesiology. 2013 Mar; 118(3): 631–639.

In this study, critically ill patients with lower vascular reactivity indicative of worse systemic endothelial function had increased duration of acute brain dysfunction.

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Previous Updates:

Endothelial Function in Hypertension: Victim or Culprit?

Telomerase and Endothelial Dysfunction

Endothelial dysfunction following prolonged sitting is mediated by a reduction in shear stress

Effects of a lifestyle intervention on endothelial function in men on long-term androgen deprivation therapy for prostate cancer

Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence.

Curr Hypertens Rep. 2016 Jan;18(2):17. 

 

Previous Featured Article:

 

Circ Res. 2016 Feb 19;118(4):620-36

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

Gimbrone MA Jr1, García-Cardeña G2.

 

1From the Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA. mgimbrone@partners.org.

  • 2From the Department of Pathology, Center for Excellence in Vascular Biology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA.

Abstract

Dysfunction of the endothelial lining of lesion-prone areas of the arterial vasculature is an important contributor to the pathobiology of atherosclerotic cardiovascular disease. Endothelial cell dysfunction, in its broadest sense, encompasses a constellation of various nonadaptive alterations in functional phenotype, which have important implications for the regulation of hemostasis and thrombosis, local vascular tone and redox balance, and the orchestration of acute and chronic inflammatory reactions within the arterial wall. In this review, we trace the evolution of the concept of endothelial cell dysfunction, focusing on recent insights into the cellular and molecular mechanisms that underlie its pivotal roles in atherosclerotic lesion initiation and progression; explore its relationship to classic, as well as more recently defined, clinical risk factors for atherosclerotic cardiovascular disease; consider current approaches to the clinical assessment of endothelial cell dysfunction; and outline some promising new directions for its early detection and treatment.
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