Cedar Sinai Study Shows MRI Not Suitable for Coronary ED Measurement

New Study

PLoS One. 2017 Jan 12;12(1):e0169818. doi: 10.1371/journal.pone.0169818. eCollection 2017.

Cold Pressor Stress Cardiac Magnetic Resonance Myocardial Flow Reserve Is Not Useful for Detection of Coronary Endothelial Dysfunction in Women with Signs and Symptoms of Ischemia and No Obstructive CAD.

Landes S1Dela Cruz S1,  Wei J1AlBadri A1Shufelt C1,  Mehta P1Thomson LE1Diniz MA2,  Zhang X2Petersen JW3Anderson RD3,  Pepine CJ3Berman DS1Bairey Merz CN1.

Author information

1Barbra Streisand Women’s Heart Center, Cedars-Sinai Heart Institute, Los Angeles, California, United States of America.

2Samuel Oschin Comprehensive Cancer Institute, Los Angeles, California, United States of America.

3Univerity of Florida, Gainesville, Florida, United States of America.

Abstract

BACKGROUND: Coronary endothelial function testing using acetylcholine is not routinely available, while non-pharmacological cold pressor testing (CPT) is considered an endothelial  stressor. Noninvasive cardiac magnetic resonance imaging (CMRI) myocardial perfusion reserve index (MPRI) can detect coronary microvascular dysfunction (CMD). We evaluated if CPT stress CMRI MPRI could detect invasive coronary endothelialdysfunction.

METHODS: Coronary reactivity testing was performed in 189 women with symptoms and signs of ischemic but no obstructive coronary artery disease as previously described plus CPT stress. Subjects also underwent pharmacologic and CPT stress during CMRI (1.5 T). Statistical analysis comparing CPT MPRI between groups was performed by Welch`s t-test and Mann-Whitney where appropriate. Anderson-Darling test and Levene test were considered to verify the normality and homogeneity of variances assumptions. Correlation analyses between CPT MPRI and both invasive and noninvasive measures of CMD were performed using Spearman correlation.

RESULTS: While CPT MPRI correlated with pharmacological stress MPRI, it did not correlate with invasive measures of CMD including invasively measured responses to intracoronary (IC) adenosine, IC acetylcholine, CPT, or IC nitroglycerin. Additionally CPT MPRI was not significantly different between subjects with normal compared to abnormal pharm stress MPRI or normal compared to abnormal invasive CMD parameters.

CONCLUSION: Despite correlation with pharmacological stress MPRI, non-invasive CPT MPRI does not appear to be useful for detecting CMD in symptomatic women.
Full-Text


See why VENDYS®
the new noninvasive, inexpensive, and automated device is superior to brachial artery ultrasound imaging of endothelial function. From research to clinic.png

New Indices of Endothelial Function Measured by Digital Thermal Monitoring of Vascular Reactivity Data from 6084 Patients Registry

Morteza Naghavi1 Albert A. Yen,2 Alex W. H. Lin,2 Hirofumi Tanaka,3 and Stanley Kleis4

Full-Text
 
 

download-pdf.jpg

Evaluate Endothelial Function with VENDYS® Digital Thermal Monitoring  of Vascular Reactivity

Endothelial Dysfunction A Systemic Disease.JPG.JPG2_houser_image.PNG
VENDYS---vascular-function-measurement-made-ea.png

Leave a Reply

LATEST SCIENTIFIC UPDATES

Enhance your patient care with the new office-based vascular function test.

Sign Up for our Webinar Series

Why Should We Measure Endothelial Function?