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Archive for the Scientific Updates Category

Clinical Examples of Microvascular Endothelial Dysfunction Consequences of COVID-19

Front Cardiovasc Med 2021 Feb 2;8:636843. Microvascular Angiopathic Consequences of COVID-19 Margaret Nalugo 1, Linda J Schulte 2, Muhammad F Masood 2, Mohamed A Zayed 1 3 4 5 Affiliations 1 Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States. 2 Division of Cardiothoracic Surgery, Department of Surgery, Washington

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New Guidelines for Endothelial Function Testing in Patient Care

 How to Use Endothelial Function Testing in Patient Care (Practical Guidelines) View / Download Slides Scientific Updates Sponsored by Endothelix Inc. View Archive

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Rheumatologists want a bigger seat at COVID research table, pointing to COVID causing auto-immune diseases (linked to hyperinflammatory endothelial dysfunction)

Ann Rheum Dis 2021 EULAR points to consider on pathophysiology and use of immunomodulatory therapies in COVID-19 Alessia Alunno # 1, Aurélie Najm # 2, Pedro M Machado 3 4 5, Heidi Bertheussen 6, Gerd R Burmester 7, Francesco Carubbi 8, Gabriele De Marco 9, Roberto Giacomelli 10, Olivier Hermine 11 12, John D Isaacs 13, Isabelle Koné-Paut 14, César Magro-Checa 15, Iain McInnes 2, Pier Luigi Meroni 16, Luca Quartuccio 17, Athimalaipet V Ramanan 18 19, Manuel Ramos-Casals 20, Javier Rodríguez Carrio 21, Hendrik Schulze-Koops 22, Tanja A Stamm 23, Sander W

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Unanswered questions about long term effects of COVID

CONCLUSION—AND UNANSWERED QUESTIONS SARS‐CoV‐2‐related inflammation and capillary damage may contribute synergistically to acute and long‐term COVID‐19 symptoms by interfering with blood and tissue oxygenation. Further studies of microvascular changes during COVID‐19—and especially subsequent capillary repair—are needed to understand capillary dysfunction’s impact on the acute and chronic health

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COVID is here to stay: Insights into new therapies targeting COVID induced mtROS overactivity, chronic inflammation, and endothelial dysfunction

Front Physiol 2021 Jan 15;11:605908. SARS-CoV-2 Mediated Endothelial Dysfunction: The Potential Role of Chronic Oxidative Stress Ryan Chang 1, Abrar Mamun 2, Abishai Dominic 3 4, Nhat-Tu Le 4 Affiliations 1 College of Arts & Sciences, Washington University in St. Louis, St. Louis, MO, United States. 2 Wiess School of Natural Sciences, Rice University, Houston,

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Endothelial Dysfunction Links COVID to DVT

Front Physiol 2021 Jan 8;11:608788. Pathophysiological Processes Underlying the High Prevalence of Deep Vein Thrombosis in Critically Ill COVID-19 Patients Sebastian Voicu 1 2, Chahinez Ketfi 3, Alain Stépanian 4 5, Benjamin G Chousterman 6 7 8, Nassim Mohamedi 3, Virginie Siguret 4 9, Alexandre Mebazaa 6 7 8, Bruno Mégarbane 1 2, Philippe Bonnin 3 10 Affiliations collapse Affiliations 1 Department of Medical and Toxicological Critical Care, Hôpital Lariboisière, APHP, Faculté de Santé,

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New MRI Study from MGH Links Neurological Consequences of COVID to Microvascular Endothelial Dysfunction

J Neurol Sci 2021 Jan 15;421:117308. . Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19 John Conklin 1, Matthew P Frosch 2, Shibani S Mukerji 3, Otto Rapalino 4, Mary D Maher 4, Pamela W Schaefer 4, Michael H Lev 4, R G Gonzalez 4, Sudeshna Das 3, Samantha N Champion 5, Colin Magdamo 3, Pritha Sen 6, G Kyle Harrold 3, Haitham Alabsi 3, Erica Normandin 7, Bennett Shaw 8, Jacob E Lemieux 6, Pardis C Sabeti 7, John A Branda 9, Emery N

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Does Ubiquinol Supplementation Improve Endothelial Dysfunction, Dementia, and HFpEF?

Antioxidants (Basel) 2021 Jan 20;10(2):E143. Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment Sonia García-Carpintero 1 2, Javier Domínguez-Bértalo 3, Cristina Pedrero-Prieto 1 2, Javier Frontiñán-Rubio 1 2, Mariano Amo-Salas 4, Mario Durán-Prado 1 2, Eloy García-Pérez 5, Julia Vaamonde 1 5, Francisco J Alcain 1 2 Affiliations collapse Affiliations ·     1 Department of Medical Sciences, Faculty of Medicine, University

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Mediterranean vs. Intermittent Fasting Diet; Which one is better for endothelial function?

Nutrients 2021 Jan 19;13(1):274. Effects of Caloric Restriction Diet on Arterial Hypertension and Endothelial Dysfunction Nicola Di Daniele 1, Giulia Marrone 1 2, Manuela Di Lauro 1, Francesca Di Daniele 1 2, Daniela Palazzetti 1, Cristina Guerriero 1, Annalisa Noce 1 Affiliations collapse Affiliations 1 UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata,

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Statin resistance or ineffective therapy? Persistent endothelial dysfunction in patients under treatment.

Int Rev Immunol 2021 Jan 13;1-19. Endothelial dysfunction sustains immune response in atherosclerosis: potential cause for ineffectiveness of prevailing drugs Shamima Akhtar 1, Alpana Sharma 1 Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India.   Abstract Vascular endothelial dysfunction (ED) forms the cornerstone in the

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