Archive for the Scientific Updates Category

J Am Coll Cardiol. 2021 Mar, 77 (12) 1564–1575 New and Emerging Therapies for Reduction of LDL-Cholesterol and Apolipoprotein B: JACC Focus Seminar 1/4 Nick S. Nurmohamed, Ann Marie Navar, and John J.P. Kastelein Abstract Adding to the foundation of statins, ezetimibe and proprotein convertase subtilisin–kexin type 9 inhibitors (PCSK9i), novel, emerging low-density

Eur J Clin Invest 2021 Mar 22 Clinical assessment of endothelial function in heart failure with preserved ejection fraction: A meta-analysis with meta-regressions Pasquale Ambrosino 1, Antimo Papa 1, Agostino Buonauro 2, Marco Mosella 1, Ilenia Calcaterra 3, Giorgio Alfredo Spedicato 4, Mauro Maniscalco 1, Matteo Nicola Dario Di Minno 5 Affiliations collapse Affiliations 1 Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy. 2

Am J Pathol 2021 Mar 10 ENDOTHELIAL CONTROL OF CEREBRAL BLOOD FLOW Julianne W Ashby 1, Julia J Mack 2 Affiliations 1 Department of Medicine, Division of Cardiology, University of California, Los Angeles. 2 Department of Medicine, Division of Cardiology, University of California, Los Angeles. Electronic address: JMack@mednet.ucla.edu. Abstract Since constant perfusion

Front Physiol 2021 . The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective Jose A Adams, Arkady Uryash, Jose R Lopez, Marvin A Sackner Affiliations collapse Affiliations Mount Sinai Medical Center, Miami Beach, FL, United States. Abstract Diabetes has reached worldwide epidemic proportions, and threatens to be

Transl Res 2021 Mar 5;S1931-5244(21)00052-9. COVID-19 and Cytokine Storm Syndrome: Are there lessons from Macrophage Activation Syndrome? Michael J Ombrello 1, Grant S Schulert 2 Affiliations 1 Translational Genetics and Genomics Unit, Pediatric Translational Research Branch, Intramural Research Program, National Institute of Arthritis and Musculoskeletal and Skin Diseases, 10 Center

Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System Jacob Roberts 1, Antonia L Pritchard 1, Andrew T Treweeke 1, Adriano G Rossi 2, Nicole Brace 1, Paul Cahill 3, Sandra M MacRury 1, Jun Wei 1, Ian L Megson 1 Affiliations 1 Institute for Health Research and Innovation, University of the

Practical Guidelines for Endothelial Function Testing in Primary Prevention and Detecting “Residual Risk” in Secondary Prevention Download Slides Download Papers Scientific Updates Sponsored by Endothelix Inc. View Archive

Therapeutic Potential of Ketone Bodies for Patients With Cardiovascular Disease: JACC Focus Seminar Salva R Yurista 1, Cher-Rin Chong 2, Juan J Badimon 3, Daniel P Kelly 4, Rudolf A de Boer 5, B Daan Westenbrink 6 Affiliations 1 University Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, the Netherlands. Electronic address: https://twitter.com/salvareverentia. 2 Basil Hetzel

JACC Editor-in-Chief’s Top 100 Picks Valentin Fuster, MD, PhD Each week, I record audio summaries for every paper in JACC, as well as an issue summary. Although this process is quite time-consuming, I have become familiar with every paper that we publish. Thus, I have personally selected the

Front Pharmacol 2021 Feb 2;12:636134. Targeting the Endothelium to Achieve Cardioprotection Nicolas Herrera-Zelada 1, Ursula Zuñiga-Cuevas 1, Andres Ramirez-Reyes 1, Sergio Lavandero 1 2, Jaime A Riquelme 1 Affiliations 1 Advanced Center for Chronic Disease (ACCDiS), Facultad de Ciencias Químicas y Farmacéuticas and Facultad de Medicina, Universidad de Chile, Santiago, Chile. 2 Department of Internal Medicine (Cardiology