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Archive for the Scientific Updates Category

Hyperuricemia was previously thought to be simply the cause of gout and gouty arthritis.

Int J Mol Sci 2021 Aug 26;22(17):9221 Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease Hidekatsu Yanai 1, Hiroki Adachi 1, Mariko Hakoshima 1, Hisayuki Katsuyama 1 Affiliations expand Abstract Uric acid (UA) is synthesized mainly in the liver,

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Considerations for Maximizing the Exercise “Drug” to Combat Insulin Resistance: Role of Nutrition, Sleep, and Alcohol

Considerations for Maximizing the Exercise “Drug” to Combat Insulin Resistance: Role of Nutrition, Sleep, and Alcohol Mary-Margaret E Remchak 1, Kelsey L Piersol 1, Sabha Bhatti 2, Andrea M Spaeth 1, Jennifer F Buckman 1 3, Steven K Malin 1 4 5 6 1 Department of Kinesiology & Health, Rutgers University, New Brunswick, NJ 08901, USA. 2 Division of Cardiovascular Medicine, Rutgers

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Does breaking up prolonged sitting improve cognitive functions in sedentary adults?

Med Sci Sports Exerc 2021 Jul 29. The Acute Effects of Prolonged Uninterrupted Sitting on Vascular Function: A Systematic Review and Meta-analysis Frances C Taylor 1, Ana J Pinto, Nirav Maniar, David W Dunstan, Daniel J Green Abstract Objective: To determine the dose-response relationship between prolonged sitting and vascular function in healthy individuals

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The Role of TRPM2 in Endothelial Function and Dysfunction

Int J Mol Sci 2021 Jul 16;22(14):7635. The Role of TRPM2 in Endothelial Function and Dysfunction Wioletta Zielińska 1, Jan Zabrzyński 2, Maciej Gagat 1, Alina Grzanka 1 Abstract The transient receptor potential (TRP) melastatin-like subfamily member 2 (TRPM2) is a non-selective calcium-permeable cation channel. It is expressed by many mammalian tissues, including bone

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Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis

Microvasc Res 2021 Jul 14;104224. Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis Andrianto 1, Makhyan Jibril Al-Farabi 2, Ricardo Adrian Nugraha 3, Bagas Adhimurda Marsudi 4, Yusuf Azmi 5 Abstract Background: Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect

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Statin and COVID

Life (Basel) 2021 Jun 16;11(6):565. Statins in COVID-19 Therapy Justyna Olszewska-Parasiewicz 1, Łukasz Szarpak 2 3, Sylwester Rogula 4, Aleksandra Gąsecka 4, Urszula Szymańska 1, Maria Kwiatkowska 1, Milosz J Jaguszewski 5, Radosław Sierpiński 6, Artur Zaczyński 1, Waldemar Wierzba 1 7, Dariusz A Kosior 1 8 Abstract Inhibitors of 3-hydroxy-3methylgultaryl-coenzyme A reductase (statins) are one of the main groups of drugs used in preventing and treating cardiovascular diseases worldwide. They

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Does balloon angioplasty improve local or systemic endothelial dysfunction in PAD patients?

Vasa 2021 Jul 8 The impact of percutaneous peripheral interventions on endothelial function Christos Rammos 1, Martin Steinmetz 1, Mirjam Johnstone 1, Anna Manzke 1, Julia Lortz 1, Olga Petrikhovich 1, Ulrike Hendgen-Cotta 1, Rolf A Jánosi 1, Tienush Rassaf 1 Affiliations collapse Affiliation Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Germany. Abstract Background: Treatment of symptomatic

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Endothelial dysfunction in people with depressive disorders: A systematic review and meta-analysis

Review J Psychiatr Res 2021 Jun 26;141:152-159. Endothelial dysfunction in people with depressive disorders: A systematic review and meta-analysis Aline J Waclawovsky 1, Edineia de Brito 2, Lee Smith 3, Davy Vancampfort 4, Antônio M V da Silva 5, Felipe B Schuch 6 Abstract The study aimed to identify whether people diagnosed with depression have endothelial dysfunction, assessed by

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Vitamin D Supplement for Lowering Blood Pressure and Improving Endothelial Function?

J Vasc Bras 2020 Jul 6;19:e20190150. doi: 10.1590/1677-5449.190150. Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease Felipe Esdras Lucas Cardoso 1, Leandro da Cruz Melgaço Dos Santos 1, Adirlene Pontes de Oliveira Tenório 1, Matheus Rodrigues Lopes 1, Romero Henrique de Almeida Barbosa 1 Abstract Vitamin D (1,25-dihydroxycolecalciferol) is a

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Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: the Maastricht Study

Brain Behav Immun 2021 Jun 26 Low-grade inflammation and endothelial dysfunction predict four-year risk and course of depressive symptoms: the Maastricht Study Eveline P C J Janssen 1, Sebastian Köhler 2, Anouk F J Geraets 3, Coen D A Stehouwer 4, Nicolaas C Schaper 5, Simone J S Sep 6, Ronald M A Henry 4, Carla J H van der Kallen 4, Casper

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