Archive for the Scientific Updates Category

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure Monia Marchetti Hematology Department, Az Osp SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. moniamarchettitamellini@gmail.com Abstract COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide. The high

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Case Report & Editorial: Home Nitric Oxide Therapy for COVID

Outpatient Inhaled Nitric Oxide in a Patient with Vasoreactive Idiopathic Pulmonary Arterial Hypertension and COVID-19 Infection Roham T. Zamanian 1,2*, Charles V. Pollack Jr.3, Michael A. Gentile 4, Moira Rashid 5, John Christian Fox 6, Kenneth W. Mahaffey 1, and Vinicio de Jesus Perez 1,2 –Author Affiliations 1Stanford University School of Medicine, Stanford, California 2Vera Moulton Wall Center for

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Home Nitric Oxide Therapy for COVID

Home Nitric Oxide Therapy for COVID Alvarez RA, Berra L, Gladwin MT. Am J Respir Crit Care Med. 2020 Jul 1;202(1):16-20. Figure 1. Summary of major therapeutic properties of inhaled nitric oxide gas (NO). From top left: inhaled NO gas is known to be a selective pulmonary

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Endothelial cell infection and endotheliitis in COVID-19

Lancet. 2020 395(10234): 1417–1418. Endothelial cell infection and endotheliitis in COVID-19 Zsuzsanna Varga,a Andreas J Flammer,b Peter Steiger,c Martina Haberecker,a Rea Andermatt,c Annelies S Zinkernagel,d Mandeep R Mehra,e Reto A Schuepbach,c Frank Ruschitzka,b and Holger Mocha Cardiovascular complications are rapidly emerging as a key threat in coronavirus disease 2019 (COVID-19) in addition to respiratory disease. The mechanisms

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New Studies Shed Light on the Link between Chronic Stress and Endothelial Dysfunction

Am J Physiol Heart Circ Physiol 2020 Jul 3. Chronic Stress and Endothelial Dysfunction: Mechanisms, Experimental Challenges and Way Ahead Lucien Derek Sher 1, Hannah Valerie Geddie 1, Lukas Olivier 1, Megan Cairns 1, Nina Truter 1, Leandrie Beselaar 1, M Faadiel Essop 1 Affiliation 1 Physiological Sciences, Stellenbosch University, South Africa. Abstract Although chronic stress is an important risk factor for

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Is coronavirus a disease of the blood vessels? An Overview from British Heart Foundation

British Heart Foundation -Heart Matters Commentary. July 1, 2020 Is coronavirus a disease of the blood vessels? As we learn more about coronavirus, it is becoming clear that it affects more than just the lungs. Phoebe Kitscha explores how and why Covid-19 affects the whole circulatory system,

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A current review of COVID-19 for the cardiovascular specialist

A current review of COVID-19 for the cardiovascular specialist Joshua P. Lang, MD,a Xiaowen Wang, MD,a Filipe A. Moura, MD, PhD,a Hasan K. Siddiqi, MD,a David A. Morrow, MD, MPH,a,b and Erin A. Bohula, MD, DPhila,b,⁎ a Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA b Critical Care Cardiology

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Endothelial Dysfunction Linked to Severe COVID-19

Crit Care. 2020; 24: 353. Published online 2020 Jun 16. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection Stéphanie Pons,1,2 Sofiane Fodil,3 Elie Azoulay,3 and Lara Zafrani1,3 Author information: 1INSERM U976, Human Immunology, Pathophysiology and Immunotherapy, Saint-Louis Teaching Hospital, Paris University, Paris, France2Anesthesia and Critical Care Department,

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New Research Points to Links Between Viral Infections and Endothelial Dysfunction

The Association of CD4+ T-Cell Count on Cardiovascular Risk in Treated HIV Disease  Emad Mogadam1,  Kevin King2, Kimberly Shriner3, Karen Chu2, Anders Sondergaard2, Kristal Young4, Morteza Naghavi5, Robert A Kloner6, 7 1Division of Cardiovascular Medicine, Department of Medicine, SUNY Upstate Medical University, Syracuse, NY, USA 2Huntington Medical Research Institutes, Pasadena, CA, USA 3Department of Medicine,

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Lifestyle Risk Factors of COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK

Brain Behav Immun. 2020 May 23 Lifestyle Risk Factors, Inflammatory Mechanisms, and COVID-19 Hospitalization: A Community-Based Cohort Study of 387,109 Adults in UK Mark Hamer,a,⁎ Mika Kivimäki,b Catharine R. Gale,c,d and G. David Battyb aDivision of Surgery and Interventional Sciences, Faculty Medical Sciences, University College London, London, UKbDepartment of Epidemiology and

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