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Case Report: Death due to COVID-19 in three brothers who lived separately and had no underlying disease. Genetic Risk Factors?

Am J Trop Med Hyg. 2020 Apr 10.
Case Report: Death Due to Novel Coronavirus Disease (COVID-19) in Three Brothers.
Yousefzadegan S1, Rezaei N2,3,4.
1 Department of Pediatric Respiratory Medicine, Firouzabadi Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2 Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
3 Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
4 Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Abstract
We report fatal cases of novel coronavirus disease (COVID-19) in three brothers in Iran. An increased susceptibility to specific pathogens has been reported for a number of genetic defects. Considering the fact that most of them who are affected by COVID-19 recover, deaths in three brothers who lived separately and had no known underlying disease suggest genetic predisposition to COVID-19 in some individuals.
“Considering the fact that most of them who are affected by COVID-19 recover, death in three brothers who lived separately is of interest. Of note, the patients’ spouses and children were not shown to be affected by COVID-19, with negative tests for SARS-CoV-2. Therefore, the three brothers who experienced fatal COVID-19 may have had a particular predisposition to infection or severe illness. It can be hypothesized that there might be a genetic predisposition to COVID-19 and/or to severe illness from COVID-19 that renders some individuals without any underlying disease at particular risk of severe or fatal illness.”
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