Endothelix has developed VENDYS®, a low-cost vascular stress test which non-invasively measures vascular reactivity, an index of vascular function, by monitoring temperature changes at the fingertip during a 2-5 minute arm cuff occlusion test. The fingertip temperature falls during the arm cuff occlusion and rebounds after the release. The extent of the temperature rebound is an indicator of the extent of blood flow. The company's proprietary analysis of the temperature fall, recovery, and overshoot reflects the state of normal or abnormal vascular function.

 

In summary: the higher the temperature rebound the healthier the artery.  

 

 

The VENDYS test has been shown to:

·        Correlate with the burden of traditional risk factors (e.g. high cholesterol, high blood pressure, smoking, etc.) as measured by Framingham Risk Score

·        Correlate with the burden of subclinical coronary artery disease as measured by coronary calcium score

·        Correlate with the severity of coronary artery disease (coronary stenosis) in symptomatic individuals as measured by CTA and invasive angiography

·        Correlate with myocardial perfusion abnormality as measured by nuclear perfusion imaging

·        Correlate with progression and regression of coronary artery disease and metabolic risk factors (measured by coronary calcium score and oxidized LDL respectively)

·        Significantly improve predictive value of traditional risk factors (measured by Framingham Risk Score) for the detection of individuals with coronary artery disease